Comparison of antipseudomonal beta-lactams for febrile neutropenia empiric therapy

Consensus on diagnosis and empiric antibiotic therapy of febrile neutropenia

Controversial issues on the management of empiric therapy and diagnosis of febrile neutropenia (FN) were faced by a Consensus Group of the Italian Association of Pediatric Hematology-Oncology (AIEOP). In this paper we report the suggestions of the consensus process regarding the role of aminoglycosides, glycopeptides and oral antibiotics in empiric therapy of FN, the rules for changing or disco...

Early Empiric Antibiotic Therapy for Febrile Neutropenia Patients at Low Risk.

Although it is apparent that certain patients with febrile neutropenic episodes can benefit from outpatient antibiotic therapy, not all low-risk patients are treated in this fashion. There are barriers, real and perceived, to implementing this approach for patients, health care providers, and caregivers. Table 3 summarizes the advantages and disadvantages of ambulatory management of febrile neu...

Institutional experience with voriconazole compared with liposomal amphotericin B as empiric therapy for febrile neutropenia.

STUDY OBJECTIVE To assess the effectiveness, safety, and cost of empiric treatment of febrile neutropenia before and after implementing an algorithm in which voriconazole was substituted for liposomal amphotericin B (L-AmB). DESIGN Retrospective cohort analysis. SETTING An 850-bed tertiary care hospital, which is also a referral site for patients with acute leukemia. PATIENTS Fifty-five a...

Utilizing Monte Carlo Simulations to Optimize Institutional Empiric Antipseudomonal Therapy.

Pseudomonas aeruginosa is a common pathogen implicated in nosocomial infections with increasing resistance to a limited arsenal of antibiotics. Monte Carlo simulation provides antimicrobial stewardship teams with an additional tool to guide empiric therapy. We modeled empiric therapies with antipseudomonal β-lactam antibiotic regimens to determine which were most likely to achieve probability o...

Evaluation of the Empiric use of Levofloxacin in Combination with Antipseudomonal Β-Lactams for the Treatment of Pneumonia